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Sir
Alexander Fleming
Scientist
1881-1955
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Sir Alexander Fleming won the Nobel
Prize for his discovery of Penicillin - as well as the antibiotic substance lysozyme
- which have both been used to
save millions of lives since.
He was born on a farm in Lochfield, in East
Ayrshire, in 1881. He was educated in nearby Kilmarnock, before attending St
Mary's Hospital Medical School in London. When World War I broke out, he - and
many of his colleagues - treated the casualties on the frontline. The incapacity
to treat the men properly drove him to develop an much better antiseptic on his
return to Britain at the end of the War.
Scientists are usually known for their
cleanliness and care. It was actually because Fleming was disorganised that his
two major discoveries were made.
He discovered Lysozyme after sneezing
into a Petri dish filled with bacteria. A few days later, he discovered that the
bacteria in the areas he had sneezed had been killed off. He deduced that the
body created its own enzyme to fight off dangerous bacteria.
His most famous discovery - Penicillin - was
the result of him running numerous experiments around the lab, without much care
as to where they ended up. It was Fleming was cleaning some of them out that he
noticed a Fungal Colony had grown next to a streak of bacteria on a sheet
of glass. The bacteria around the fungus had died, as the cells were breaking
down (known as lysis). Although he knew this was significant, he didn't realise
that it would become one the greatest discoveries of the century.
He played with growing the mould for some
time, but eventually gave up - feeling that it would be too difficult to
manufacture on a scale that would be useful. He passed the process over Howard Florey and
Ernst Boris Chain, who perfected the process of purification - and were
able to make it available in time for World War II. It is believed to have saved
millions of lives during the six-year period.
For their work, Fleming, Florey and Chain
jointly received the Nobel Prize for Medicine in 1945. Fleming had been
knighted a year earlier.
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